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Coming dissertations at Uppsala university

  • In the Image of Loss : A new perspective on the works of Johan Huizinga (1872–1945) Author: Thor Rydin Link: Publication date: 2022-05-19 13:08

    "I no longer understand it, and I no longer care for it," Johan Huizinga, Professor of General History at Leiden University, said about his own field to his undoubtedly perplexed students at the opening of the academic year in 1919. The Great War had shocked him to the bone: states, traditions, norms and communities that until only recently had seemed part of life’s unquestionable fabric had been torn apart – and though Huizinga did not know at the time, more experiences of loss and upheaval were soon to follow. Other than he announced in 1919, however, Huizinga continued to "care" for and write history after the war; or rather, "history" became a way of "caring" for himself and others in times of rupture. Today, Huizinga is commonly ranked among the most eminent cultural historians of his century.

    This dissertation examines through the lens of Huizinga’s work how "experiences of loss" mediated not only a different angle on particular historical periods but renegotiated the meaning and purpose of "history" just before and during the interwar period. Against the background of loss, "history" became a way of life to Huizinga – a way of organizing thoughts and passions in unsteady times. By making this argument, this dissertation makes two claims: one historical, the other historiographical. Historically, it offers a new and original perspective on an iconic and celebrated historian and his times. Historiographically, it produces a case in point for an "experiential" approach to authors, and historians in particular, writing in times of great uncertainty.

  • Respect for People : Developing alternative understandings and relationships to ethics, leadership, and culture in Lean implementations. Author: Mia Ljungblom Link: Publication date: 2022-05-19 13:03

    Successful Lean implementation is a combination of both technology and culture, using bothkey principles of continuous improvement (CI) and respect for people (RFP). However, manyorganizations fail to implement Lean and critical factors in this failure are leadership, cultureand the lack of RFP. When CI and RFP permeate an organization, it is called real Lean, andwhen there is only a focus on CI it is called false Lean. Without Lean culture, where RFP playsthe main role, Lean becomes an add-on tool.

    The purpose of this thesis is twofold. The first part of the purpose is to developalternative understandings of RFP and relationships to ethics, leadership and culture in Leanimplementations. The second part is to suggest a normative framework helping leaders toachieve real Lean.

    The purpose is operationalized into the following research questions: - What understandingsof RFP can enable Lean implementations? - What understandings of ethics, leadership andculture can enable Lean implementations? - How can these understandings form a normativeframework for Lean leaders?

    The study is a qualitative, exploratory and descriptive case study with anabductive approach. The data have been collected by documents, interviews, questionnaires,and participant observations. Content and discourse analysis are used together with pattern-matchingto analyse the data.

    The study shows that it is important to understand the differences in culture (national/organizational) prior to Lean implementation and to conduct an organizational analysis to findsimilarities and differences between Lean and organizational values. The study also finds thatRFP is composed of elements in different cultural levels. The elements identified are ethics,leadership and culture, each of which has invisible elements, often linked to Japanese religionsand traditions, that need to be visualized and discussed. Previous research has presented variousframeworks and models exist but these are more know-what than know-how. Organizationsneed more know-how to create real Lean where RFP can be seen as the ‘how’.

    I developed a leadership model called Developmental Lean leadership (DLL) that aims tofind leadership that supports both employee and organizational development and can meet theneeds of a Lean leader, which are to act as a role model and support the development towardsa real Lean culture.

    I also developed a normative framework for Lean leaders called the RFP house, which it ishoped will help Lean leaders achieve real Lean in their organizations during implementations.

  • The Biological Importance of the Amino Acid Transporter SLC38A10 : Characterization of a Knockout Mouse Author: Frida A. Lindberg Link: Publication date: 2022-05-19 10:34

    The biggest group of transporters, the solute carriers (SLCs), has more than 400 members, and about 30% of these are still orphan. In order to decipher their biological function and possible role in disease, there is a need for characterization of these. Around 25% of SLCs are estimated to have amino acids as substrates, including transporters belonging to the SLC38 family. The SLC38 members are sometimes referred to their alternative name: sodium-coupled neutral amino acid transporters (SNATs). One of these transporters, SNAT10 (or SLC38A10), has been characterized as a bidirectional transporter of glutamate, glutamine, alanine and aspartate, as well as having an efflux of serine, and is ubiquitously expressed in the body. However, its biological importance is not yet understood. The aim with this thesis was to characterize a mouse model deficient in SNAT10 protein in order to find the biological importance of this transporter. In paper I, this is done by using a series of behavioral tests, including the open field test, elevated plus maze, rotarod and Y-maze, among others. The SNAT10 knockout mouse was found to have an increased risk-taking behavior, but no motor or spatial working memory impairments. Furthermore, the knockout mouse was found to have a decreased body weight. In paper II, an additional behavioral characterization was performed by using the multivariate concentric square field™ (MCSF) test. The MCSF test is an arena with different zones associated to different behavioral traits, which generates a behavioral profile depending on where the mouse spends its time. The result from this test implies that the SNAT10 deficient mouse has a lower explorative behavior than its wild type littermates. In paper III, gene expression was studied in whole brain and some genes related to cell cycle regulation and p53 expression were found to be differentially expressed in the knockout brain. Additional gene expression was studied in kidney, liver, lung and muscle, but no changes were found. Plasma levels of histidine and threonine were altered in males, but no altered amino acid levels were found in knockout females, suggesting a possible sex-specific effect. These studies together imply that SNAT10 might be involved in processes related to risk-taking and explorative behavior in the open field and MCSF tests. SNAT10 deficiency also affected amino acid levels in plasma, indicating a disrupted amino acid homeostasis.