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Coming dissertations at Uppsala university

  • Quest for Sociology : Revisiting Prevailing Understandings of a Discipline with Computational Text Analyses of Dissertations Author: Josef Ginnerskov Link: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521096 Publication date: 2024-02-14 12:05

    What is sociology? For centuries sociologists have struggled to answer this question and repeatably proclaimed that their discipline is in crisis. The problem has generated a field of its own, the sociology of sociology, where sociologists of knowledge offer concepts for how the paradigmatic status of discipline and its crisis ought to be understood. Yet, the foundation of these understandings has often been limited to conceptual reasonings, historical exposes, and anecdotes from prominent scholars. Following the increasing availability of digitized texts and the development of computational techniques, new venues have been opened for investigating the empirical bearing of what sociology is. This dissertation offers a synthesis of, and a contribution to, this growing literature at the intersection of the sociology of knowledge and computational social science.

    The starting point is a review of literature in the sociology of sociology that has found that our discipline is believed to exist in a state of fragmentation, lacks a paradigm, and is conditioned by the context of its production. Akin to the supposed crisis, these conceptualizations are often taken for granted rather than being empirically put to test. This is why this dissertation aims to shed new light on the crisis of sociology by empirically scrutinizing prevailing disciplinary understandings with an interpretative and theory-driven methodological approach to computational text analysis (i.e., word correlation networks, topic modeling, stylometry, and shallow neural networks). 

    To account for textual representations of sociological knowledge that are firmly institutionalized and exist across different local contexts, hundreds of dissertations in this discipline published in Sweden between 1980 and 2019 by five main universities have been digitized to form two corpora – 380 full-texts and 850 abstracts. Using these corpora, the conceptualizations are operationalized to be able to scrutinize, and trace, reoccurring instances where dissertations allude to certain images of sociology, which, drawing on the work of Margaret Masterman, can be regarded as crude replicas of paradigms. The study design allows us to problematize prevailing understandings of what sociology is.

    In contrast to the notion of fragmentation, the corpora are constituted by a core conditioned by local institutions attuned to different paradigmatic images of sociology. A discrepancy is also found between the two corpora where the abstracts appear to follow a divide between qualitative and quantitative research, and the full-texts are characterized by five paradigms with distinct methodological, epistemological, and ontological positions. These results suggest that the coexistence of multiple paradigms has been conflated with fragmentation and that sociologists tend to present their knowledge along the lines of simplified dichotomies. In response to the crisis, a more fruitful approach might be to embrace paradigm pluralism.

    As a contribution to the sociology of knowledge, this dissertation is an example of how the methodological divide can be overcome by merging insights from the conceptual strand with a hermeneutical take on computational methods to empirically explore taken-for-granted assumptions behind the production of disciplinary knowledge.

  • Risk factors for incident heart failure and atrial fibrillation in an elderly population : The role of cardiac conduction and heart rate variability Author: Bozena Ostrowska Link: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-518489 Publication date: 2024-02-13 09:37

    Heart failure (HF) and atrial fibrillation (AF) are epidemic diseases, frequently coexisting, sharing risk factors and conferring poor prognosis. Identification of individuals at high risk of HF and AF may enable early treatment and improve the prognosis. Reliable prediction models for daily clinical practice are lacking. Early modification and treatment of risk factors may reduce the incidence of AF and HF. Because atrial structure and function abnormalities increase the risk of AF, ECG indices reflecting atrial pathology may prove useful in predicting AF and HF.

    The main objectives were to evaluate whether:

    • P-wave duration (Pdur) and PR-interval in V1 predicted incident HF and incident AF (Paper I-II)
    • low frequency/high frequency (L-F/H-F) ratio, a marker of autonomic balance, predicted incident HF (Paper IV)
    • combining selected ECG variables or the L-F/H-F ratio with traditional risk factors improved the performance of the traditional HF prediction model (Paper III-IV).

    The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) with 15 years of follow-up was used for all four studies. After applying the exclusion criteria, 836 subjects were evaluated for incident HF (Paper I, III-IV) and 877 subjects for incident AF (Paper II). Cox proportional hazard analysis related ECG-derived variables to incident HF and incident AF. Study III used machine learning to determine which ECG variables correlated to incident HF. C-statistic was used to test whether adding selected ECG variables to traditional HF risk factors improved the performance of the HF prediction model.

    Short Pdur was significantly associated with incident HF (Paper I) and incident AF (Paper II). Of 134 ECG variables, high R-wave amplitude variation (SD Ramp) had the highest predictive value for HF (Paper III). A decreased L-F/H-F ratio significantly predicted HF (Paper IV). Adding eight selected ECG variables (Paper III) and the L-F/H-F ratio (Paper IV) to the traditional risk factors significantly improved HF predictive performance by 11.7% and 3.3%, respectively.

    In conclusion, the ECG may prove useful for predicting incident HF and AF beyond the traditional risk factors. An autonomic imbalance may precede the development of HF.

  • Articulation and velopharyngeal function in patients with cleft lip and/or palate : Outcome predictors Author: Åsa Okhiria Link: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-519479 Publication date: 2024-02-09 09:22

    Cleft lip and/or palate is the most common congenital craniofacial malformation, requiring multidisciplinary treatment, including surgery and often speech therapy. Palatal surgery restores the anatomical barrier between the oral and nasal cavities as well as the palatal function needed for normal speech.

    The present thesis aimed to investigate factors thought to impact surgical and speech outcomes. These factors include the timing of surgery, surgical technique, the surgeon's experience, cleft type, and cleft width.

    Study I investigated the impact of cleft type and width on velopharyngeal function (VPF) and secondary surgery rates from ages three to 16. Cleft width was associated with increased surgery rates and signs of velopharyngeal insufficiency (VPI) at ages three and five. Contrary to some previous studies, surgery rates and speech outcomes were not associated with cleft type at any age.

    Study II examined VPF and articulation development between ages five and ten in children adopted from China compared to Swedish-born children. Adoptees had palatoplasty later and had more severe articulation difficulties at both ages. The number of adoptees and non-adoptees with VPI was similar, but fewer adoptees had competent VPF.

    Study III explored different types of intra-velar veloplasty and the impact of cleft width and surgeon experience on outcomes in 5-year-old children. Radical muscle dissection was not superior to intra-velar veloplasty reinforced by the palatopharyngeal muscle. Cleft width had a more significant impact on secondary surgery rates and VPF than did surgical technique—neither affected articulation proficiency.

    Study IV examined the association between cleft type and width and surgical and speech outcomes, especially articulation, in 5-year-old children. Cleft width, not type, indicated articulation proficiency. The same errors occurred across all cleft types. Neither cleft type nor width was significantly associated with secondary surgery rates or VPF.

    The present thesis highlights the importance of considering various factors when predicting secondary palatal surgery rates and speech outcomes. Cleft width significantly affects secondary surgery rates, VPF, and articulation proficiency, while cleft type and surgical technique do not. Adopted children are at higher risk of persistent articulation errors, which may partly be due to their later palatoplasty. 

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